Once you finish the Diablo 4 campaign and begin the post-level 50 grind, you start running dungeons regularly for rare loot, and for the XP payouts that will give Paragon Points, and get you to level 100.
Nightmare Dungeons is a variant of existing dungeons that comes with unique modifiers. Of course, they're all intended to make things more challenging for players. Blizzard recently buffed XP payouts in Nightmare Dungeons significantly, so more and more see them as a viable option for endgame grind.
One such modifier, Avenger, can make things interesting in a different way, beyond the difficulty spike. Avenger can result in enemies getting a lot larger than you're used to. The affliction makes it so enemies in the vicinity of others you're currently fighting get stronger - and bigger over time.
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